1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE

1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE - Names and Identifiers

Name	4-(difluoromethoxy)benzylamine
Synonyms	RARECHEM AL BW 0728 4-(DIFLUOROMETHOXY)BENZYLAMINE 4-(difluoromethoxy)benzylamine [4-(Difluoromethoxy)phenyl]methanamine [4-(Difluoromethoxy)phenyl]methylamine 1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE 1-[4-(difluoromethoxy)phenyl]methanamine Benzenemethanamine, 4-(difluoromethoxy)- (9CI)
CAS	177842-14-7
InChI	InChI=1/C8H9F2NO/c9-8(10)12-7-3-1-6(5-11)2-4-7/h1-4,8H,5,11H2

1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE - Physico-chemical Properties

Molecular Formula	C8H9F2NO
Molar Mass	173.16
Density	1.196
Boling Point	227℃
Flash Point	91℃
Vapor Presure	0.0781mmHg at 25°C
Appearance	Colorless or yellow liquid
BRN	4180270
pKa	8.90±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive	Air Sensitive
Refractive Index	1.491
MDL	MFCD00236231

1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2735
Hazard Note	Irritant
Hazard Class	8
Packing Group	II

1-[4-(DIFLUOROMETHOXY)PHENYL]METHANAMINE - Introduction

4-(difluoromethoxy)benzylamine is an organic compound with the chemical formula C8H8F2NO. It is a colorless liquid with a pungent odor. The following is an introduction to the properties, uses, formulation and safety information of 4-(difluoromethoxy)benzylamine:

Nature:
1. Appearance: colorless liquid
2. Density: 1.305 g/cm
3. Melting point:-48 ° C
4. Boiling point: 200 ° C
5. Flash point: 201 °F
6. Solubility: Soluble in most organic solvents, such as ethanol, methanol and dichloromethane.

Use:
1. Drug intermediates: 4-(difluoromethoxy)benzylamine can be used as an intermediate for the synthesis of antidepressant drugs, such as quetiapine.
2. Pesticide intermediates: It can also be used to synthesize pesticides, such as methylaminothiazide.
3. Organic synthesis: It is a commonly used reagent in organic synthesis and can be used to synthesize various organic compounds.

Method:
4-(difluoromethoxy)benzylamine can be prepared by reacting 4-hydroxybenzylamine with difluoromethylmagnesium chloride.

Safety Information:
1.4-(difluoromethoxy)benzylamine is irritating and should be used with appropriate protective equipment.
2. Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water.
3. Should be used in a well-ventilated place, avoid inhalation or intake.
4. Please store properly, avoid contact with oxidizing agent and strong acid.
5. In the use of 4-(difluoromethoxy)benzylamine, should carefully read and comply with the relevant safety procedures.

Last Update：2024-04-09 02:00:43